PMID- 9215864
OWN - NLM
STAT- MEDLINE
DCOM- 19970728
LR  - 20220309
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 116
IP  - 2
DP  - 1997 Jun 24
TI  - Inhibitory effect of dietary curcumin on skin carcinogenesis in mice.
PG  - 197-203
AB  - Laboratory animal model studies have suggested that curcumin may play an 
      important role in inhibiting the process of carcinogenesis. Curcumin, the yellow 
      pigment that is obtained from rhizomes of the plant Curcuma longa Linn (Family 
      Zingiberaceae), is commonly used as a spice and food coloring agent. The present 
      study was designed to investigate the chemopreventive action of dietary curcumin 
      on 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 
      12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin tumor formation in male 
      Swiss ablino mice. At 6 weeks of age, groups of animals were fed the standard 
      (modified AIN-76 A) diet or a diet containing 1% curcumin. At 8 weeks of age, all 
      animals, except those in the vehicle (acetone)-treated groups, received 100 
      microg of DMBA dissolved in 100 microl of acetone in a single application to the 
      skin of the back. From 1 week after DMBA application, tumor promoter (2.5 microg 
      of TPA dissolved in 100 microl of acetone) was applied to the same areas on mouse 
      skin twice a week for 26 weeks. All groups continued on their respective dietary 
      regimen until the termination of the experiment. The results indicate that 
      dietary administration of curcumin significantly inhibited the number of tumors 
      per mouse (P < 0.05) and the tumor volume (P < 0.01). The percentage of 
      tumor-bearing mice tended to be lower in the mice on the curcumin diet than those 
      on the standard diet. There was no difference in growth between mice of the 
      standard and 1% curcumin groups. The results indicate the safety and the 
      anti-carcinogenic effect of curcumin in mice.
FAU - Limtrakul, P
AU  - Limtrakul P
AD  - Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand.
FAU - Lipigorngoson, S
AU  - Lipigorngoson S
FAU - Namwong, O
AU  - Namwong O
FAU - Apisariyakul, A
AU  - Apisariyakul A
FAU - Dunn, F W
AU  - Dunn FW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Anticarcinogenic Agents)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - IT942ZTH98 (Curcumin)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene
MH  - Animals
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Curcumin/*pharmacology
MH  - Male
MH  - Mice
MH  - Skin Neoplasms/*prevention & control
MH  - Tetradecanoylphorbol Acetate
EDAT- 1997/06/24 00:00
MHDA- 1997/06/24 00:01
CRDT- 1997/06/24 00:00
PHST- 1997/06/24 00:00 [pubmed]
PHST- 1997/06/24 00:01 [medline]
PHST- 1997/06/24 00:00 [entrez]
AID - S0304-3835(97)00187-0 [pii]
AID - 10.1016/s0304-3835(97)00187-0 [doi]
PST - ppublish
SO  - Cancer Lett. 1997 Jun 24;116(2):197-203. doi: 10.1016/s0304-3835(97)00187-0.