PMID- 9230312
OWN - NLM
STAT- MEDLINE
DCOM- 19970826
LR  - 20220129
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 90
IP  - 1
DP  - 1997 Jul 11
TI  - Pax6 controls progenitor cell identity and neuronal fate in response to graded 
      Shh signaling.
PG  - 169-80
AB  - Distinct classes of motor neurons and ventral interneurons are generated by the 
      graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by 
      establishing different progenitor cell populations in the ventral neural tube 
      that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct 
      ventral progenitor cell populations and controls the identity of motor neurons 
      and ventral interneurons, mediating graded Shh signaling in the ventral spinal 
      cord and hindbrain.
FAU - Ericson, J
AU  - Ericson J
AD  - Howard Hughes Medical Institute, Department of Biochemistry and Molecular 
      Biophysics, Columbia University, New York, New York 10032, USA.
FAU - Rashbass, P
AU  - Rashbass P
FAU - Schedl, A
AU  - Schedl A
FAU - Brenner-Morton, S
AU  - Brenner-Morton S
FAU - Kawakami, A
AU  - Kawakami A
FAU - van Heyningen, V
AU  - van Heyningen V
FAU - Jessell, T M
AU  - Jessell TM
FAU - Briscoe, J
AU  - Briscoe J
LA  - eng
GR  - MC_U127527199/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Homeobox Protein Nkx-2.2)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (nkx2.2b protein, zebrafish)
SB  - IM
MH  - Animals
MH  - Chick Embryo
MH  - DNA-Binding Proteins/biosynthesis/*physiology
MH  - *Embryonic Induction
MH  - Eye Proteins
MH  - Hedgehog Proteins
MH  - Homeobox Protein Nkx-2.2
MH  - Homeodomain Proteins/biosynthesis
MH  - Interneurons/classification/cytology/physiology
MH  - Motor Neurons/classification/cytology/physiology
MH  - Nervous System/cytology/*embryology
MH  - Neurons/cytology/*physiology
MH  - Organ Culture Techniques
MH  - PAX6 Transcription Factor
MH  - Paired Box Transcription Factors
MH  - Proteins/*physiology
MH  - Repressor Proteins
MH  - Rhombencephalon/cytology/embryology
MH  - Signal Transduction
MH  - Spinal Cord/cytology/embryology
MH  - Stem Cells/*cytology/*physiology
MH  - *Trans-Activators
MH  - Transcription Factors/biosynthesis/*physiology
MH  - Zebrafish Proteins
EDAT- 1997/07/11 00:00
MHDA- 1997/07/11 00:01
CRDT- 1997/07/11 00:00
PHST- 1997/07/11 00:00 [pubmed]
PHST- 1997/07/11 00:01 [medline]
PHST- 1997/07/11 00:00 [entrez]
AID - S0092-8674(00)80323-2 [pii]
AID - 10.1016/s0092-8674(00)80323-2 [doi]
PST - ppublish
SO  - Cell. 1997 Jul 11;90(1):169-80. doi: 10.1016/s0092-8674(00)80323-2.