PMID- 9244297
OWN - NLM
STAT- MEDLINE
DCOM- 19970828
LR  - 20211203
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 90
IP  - 2
DP  - 1997 Jul 25
TI  - Hedgehog elicits signal transduction by means of a large complex containing the 
      kinesin-related protein costal2.
PG  - 225-34
AB  - The hedgehog gene of Drosophila melanogaster encodes a secreted protein (HH) that 
      plays a vital role in cell fate and patterning. Here we describe a protein 
      complex that mediates signal transduction from HH. The complex includes the 
      products of at least three genes: fused (a protein-serine/threonine kinase), 
      cubitus interruptus (a transcription factor), and costal2 (a kinesin-like 
      protein). The complex binds with great affinity to microtubules in the absence of 
      HH, but binding is reversed by HH. Mutations in the extracatalytic domain of FU 
      abolish both the biological function of the protein and its association with 
      COS2. We conclude that the complex may facilitate signaling from HH by governing 
      access of the cubitus interruptus protein to the nucleus.
FAU - Robbins, D J
AU  - Robbins DJ
AD  - G.W. Hooper Foundation and Department of Microbiology and Immunology, University 
      of California, San Francisco, 94143-0552, USA.
FAU - Nybakken, K E
AU  - Nybakken KE
FAU - Kobayashi, R
AU  - Kobayashi R
FAU - Sisson, J C
AU  - Sisson JC
FAU - Bishop, J M
AU  - Bishop JM
FAU - Therond, P P
AU  - Therond PP
LA  - eng
GR  - CA44338/CA/NCI NIH HHS/United States
GR  - CA45508/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (ci protein, Drosophila)
RN  - 0 (cos protein, Drosophila)
RN  - 149291-21-4 (hh protein, Drosophila)
RN  - EC 2.7.1.- (fu protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 3.6.4.4 (Kinesins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/chemistry/growth & development/*physiology
MH  - Embryo, Nonmammalian/chemistry/physiology
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Hedgehog Proteins
MH  - Insect Proteins/*genetics/metabolism
MH  - Kinesins/*genetics/metabolism/*pharmacology
MH  - Microtubules/metabolism
MH  - Phosphorylation
MH  - Protein Binding/physiology
MH  - Protein Serine-Threonine Kinases/chemistry/genetics/metabolism
MH  - Protein Structure, Tertiary
MH  - Signal Transduction/*physiology
MH  - Transcription Factors
MH  - Zinc Fingers/genetics
EDAT- 1997/07/25 00:00
MHDA- 1997/07/25 00:01
CRDT- 1997/07/25 00:00
PHST- 1997/07/25 00:00 [pubmed]
PHST- 1997/07/25 00:01 [medline]
PHST- 1997/07/25 00:00 [entrez]
AID - S0092-8674(00)80331-1 [pii]
AID - 10.1016/s0092-8674(00)80331-1 [doi]
PST - ppublish
SO  - Cell. 1997 Jul 25;90(2):225-34. doi: 10.1016/s0092-8674(00)80331-1.