PMID- 9252323
OWN - NLM
STAT- MEDLINE
DCOM- 19970902
LR  - 20240109
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 277
IP  - 5328
DP  - 1997 Aug 15
TI  - daf-2, an insulin receptor-like gene that regulates longevity and diapause in 
      Caenorhabditis elegans.
PG  - 942-6
AB  - A C. elegans neurosecretory signaling system regulates whether animals enter the 
      reproductive life cycle or arrest development at the long-lived dauer diapause 
      stage. daf-2, a key gene in the genetic pathway that mediates this endocrine 
      signaling, encodes an insulin receptor family member. Decreases in DAF-2 
      signaling induce metabolic and developmental changes, as in mammalian metabolic 
      control by the insulin receptor. Decreased DAF-2 signaling also causes an 
      increase in life-span. Life-span regulation by insulin-like metabolic control is 
      analogous to mammalian longevity enhancement induced by caloric restriction, 
      suggesting a general link between metabolism, diapause, and longevity.
FAU - Kimura, K D
AU  - Kimura KD
AD  - Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 
      02114, USA.
FAU - Tissenbaum, H A
AU  - Tissenbaum HA
FAU - Liu, Y
AU  - Liu Y
FAU - Ruvkun, G
AU  - Ruvkun G
LA  - eng
SI  - GENBANK/AF012437
GR  - R01AG14161/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Insulin)
RN  - 0 (Phosphatidylinositol Phosphates)
RN  - 0 (phosphatidylinositol 3,4,5-triphosphate)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 2.7.10.1 (DAF-2 protein, C elegans)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - EC 2.7.10.1 (insulin receptor-related receptor)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CIN - Science. 1997 Aug 15;277(5328):897-8. PMID: 9281069
MH  - Adipose Tissue/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans/chemistry/*genetics/growth & development/metabolism
MH  - Caenorhabditis elegans Proteins
MH  - Chromosome Mapping
MH  - Conserved Sequence
MH  - Energy Intake
MH  - *Genes, Helminth
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Larva/genetics/growth & development/metabolism
MH  - Longevity/*genetics
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phosphatidylinositol 3-Kinases
MH  - Phosphatidylinositol Phosphates/metabolism
MH  - Phosphorylation
MH  - Phosphotransferases (Alcohol Group Acceptor)/metabolism
MH  - Receptor, IGF Type 1/chemistry/genetics
MH  - Receptor, Insulin/chemistry/*genetics/metabolism
MH  - Signal Transduction
EDAT- 1997/08/15 00:00
MHDA- 1997/08/15 00:01
CRDT- 1997/08/15 00:00
PHST- 1997/08/15 00:00 [pubmed]
PHST- 1997/08/15 00:01 [medline]
PHST- 1997/08/15 00:00 [entrez]
AID - 10.1126/science.277.5328.942 [doi]
PST - ppublish
SO  - Science. 1997 Aug 15;277(5328):942-6. doi: 10.1126/science.277.5328.942.