PMID- 9287210
OWN - NLM
STAT- MEDLINE
DCOM- 19970929
LR  - 20240109
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 277
IP  - 5332
DP  - 1997 Sep 12
TI  - STATs and gene regulation.
PG  - 1630-5
AB  - STATs (signal transducers and activators of transcription) are a family of latent 
      cytoplasmic proteins that are activated to participate in gene control when cells 
      encounter various extracellular polypeptides. Biochemical and molecular genetic 
      explorations have defined a single tyrosine phosphorylation site and, in a 
      dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, 
      a DNA interaction domain, and a number of protein-protein interaction domains 
      (with receptors, other transcription factors, the transcription machinery, and 
      perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial 
      roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and 
      most recently in Dictyostelium discoideum, implies an ancient evolutionary origin 
      for this dual-function set of proteins.
FAU - Darnell, J E Jr
AU  - Darnell JE Jr
AD  - Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, 
      USA.
LA  - eng
GR  - AI32489/AI/NIAID NIH HHS/United States
GR  - AI34420/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - DNA/*metabolism
MH  - DNA-Binding Proteins/chemistry/genetics/*metabolism
MH  - Dimerization
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Nuclear Proteins/metabolism
MH  - Phosphorylation
MH  - Phosphotyrosine/metabolism
MH  - *Signal Transduction
MH  - Trans-Activators/chemistry/genetics/*metabolism
MH  - *Transcriptional Activation
MH  - src Homology Domains
RF  - 99
EDAT- 1997/09/12 00:00
MHDA- 2001/03/28 10:01
CRDT- 1997/09/12 00:00
PHST- 1997/09/12 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1997/09/12 00:00 [entrez]
AID - 10.1126/science.277.5332.1630 [doi]
PST - ppublish
SO  - Science. 1997 Sep 12;277(5332):1630-5. doi: 10.1126/science.277.5332.1630.