PMID- 9315452
OWN - NLM
STAT- MEDLINE
DCOM- 19971119
LR  - 20220408
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 32
IP  - 4-5
DP  - 1997 Jul-Oct
TI  - Age-related changes in the blood-brain barrier.
PG  - 501-19
AB  - Aging of the cerebral microcirculation results in significant alteration in the 
      blood-brain barrier (BBB). The barrier function appears to remain intact in older 
      animals, although it may be more susceptible to disruption by external factors 
      (hypertension) and drugs (haloperidol). While overall transport processes do not 
      change with age, aging animals and humans have altered BBB function of select 
      carrier mediated transport systems including the transport of choline, glucose, 
      butyrate and triiodothyronine. These age-related changes are the result of either 
      alteration in the carrier molecules or the physiochemical properties of the 
      cerebral microvessels. At the present time, it is not known whether changes in 
      the BBB contribute to the age-related neurodegenerative diseases or are merely 
      epiphenomena of aging.
FAU - Shah, G N
AU  - Shah GN
AD  - Department of Internal Medicine, St. Louis University, School of Medicine, MO 
      63104, USA.
FAU - Mooradian, A D
AU  - Mooradian AD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Antigens)
RN  - 0 (Carrier Proteins)
RN  - 0 (Enzymes)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Antigens/physiology
MH  - Biological Transport
MH  - Blood-Brain Barrier/*physiology
MH  - Capillaries/physiology
MH  - Carrier Proteins/metabolism
MH  - Cerebrovascular Circulation
MH  - Endothelium, Vascular/physiology
MH  - Enzymes/physiology
MH  - Humans
RF  - 187
EDAT- 1997/07/01 00:00
MHDA- 1997/10/07 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/10/07 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - S0531-5565(96)00158-1 [pii]
AID - 10.1016/s0531-5565(96)00158-1 [doi]
PST - ppublish
SO  - Exp Gerontol. 1997 Jul-Oct;32(4-5):501-19. doi: 10.1016/s0531-5565(96)00158-1.