PMID- 9334309
OWN - NLM
STAT- MEDLINE
DCOM- 19971105
LR  - 20220311
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 278
IP  - 5337
DP  - 1997 Oct 17
TI  - Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling 
      pathway.
PG  - 477-83
AB  - A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia 
      inhibitory factor cytokine family regulate gliogenesis in the developing 
      mammalian central nervous system was characterized. Activation of the CNTF 
      receptor promoted differentiation of cerebral cortical precursor cells into 
      astrocytes and inhibited differentiation of cortical precursors along a neuronal 
      lineage. Although CNTF stimulated both the Janus kinase-signal transducer and 
      activator of transcription (JAK-STAT) and Ras-mitogen-activated protein kinase 
      signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway 
      selectively enhanced differentiation of these precursors along a glial lineage. 
      These findings suggest that cytokine activation of the JAK-STAT signaling pathway 
      may be a mechanism by which cell fate is controlled during mammalian development.
FAU - Bonni, A
AU  - Bonni A
AD  - Division of Neuroscience, Children's Hospital, and Department of Neurobiology, 
      Harvard Medical School, Boston, MA 02115, USA.
FAU - Sun, Y
AU  - Sun Y
FAU - Nadal-Vicens, M
AU  - Nadal-Vicens M
FAU - Bhatt, A
AU  - Bhatt A
FAU - Frank, D A
AU  - Frank DA
FAU - Rozovsky, I
AU  - Rozovsky I
FAU - Stahl, N
AU  - Stahl N
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
FAU - Greenberg, M E
AU  - Greenberg ME
LA  - eng
GR  - NIHP30-HD 18655/HD/NICHD NIH HHS/United States
GR  - R01 CA43855/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Il6st protein, rat)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Leukemia Inhibitory Factor Receptor alpha Subunit)
RN  - 0 (Lifr protein, rat)
RN  - 0 (Lymphokines)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, OSM-LIF)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, rat)
RN  - 0 (Trans-Activators)
RN  - 133483-10-0 (Cytokine Receptor gp130)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Jak1 protein, rat)
RN  - EC 2.7.10.2 (Janus Kinase 1)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Astrocytes/*cytology/drug effects/metabolism
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Lineage
MH  - Cells, Cultured
MH  - Cerebral Cortex/*cytology/embryology
MH  - Ciliary Neurotrophic Factor
MH  - Cytokine Receptor gp130
MH  - DNA-Binding Proteins/*metabolism
MH  - Dimerization
MH  - Glial Fibrillary Acidic Protein/biosynthesis
MH  - Growth Inhibitors/metabolism/pharmacology
MH  - *Interleukin-6
MH  - Janus Kinase 1
MH  - Leukemia Inhibitory Factor
MH  - Leukemia Inhibitory Factor Receptor alpha Subunit
MH  - Lymphokines/metabolism/pharmacology
MH  - Membrane Glycoproteins/metabolism
MH  - Nerve Growth Factors/pharmacology
MH  - Nerve Tissue Proteins/metabolism/pharmacology
MH  - Platelet-Derived Growth Factor/pharmacology
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Rats
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Cytokine/metabolism
MH  - Receptors, Nerve Growth Factor/metabolism
MH  - Receptors, OSM-LIF
MH  - STAT1 Transcription Factor
MH  - STAT3 Transcription Factor
MH  - *Signal Transduction
MH  - Stem Cells/cytology
MH  - Trans-Activators/*metabolism
EDAT- 1997/10/23 00:00
MHDA- 1997/10/23 00:01
CRDT- 1997/10/23 00:00
PHST- 1997/10/23 00:00 [pubmed]
PHST- 1997/10/23 00:01 [medline]
PHST- 1997/10/23 00:00 [entrez]
AID - 10.1126/science.278.5337.477 [doi]
PST - ppublish
SO  - Science. 1997 Oct 17;278(5337):477-83. doi: 10.1126/science.278.5337.477.