PMID- 9336221
OWN - NLM
STAT- MEDLINE
DCOM- 19971120
LR  - 20231120
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 387
IP  - 2
DP  - 1997 Oct 20
TI  - Regional differences in synaptogenesis in human cerebral cortex.
PG  - 167-78
AB  - The formation of synaptic contacts in human cerebral cortex was compared in two 
      cortical regions: auditory cortex (Heschl's gyrus) and prefrontal cortex (middle 
      frontal gyrus). Synapse formation in both cortical regions begins in the fetus, 
      before conceptual age 27 weeks. Synaptic density increases more rapidly in 
      auditory cortex, where the maximum is reached near postnatal age 3 months. 
      Maximum synaptic density in middle frontal gyrus is not reached until after age 
      15 months. Synaptogenesis occurs concurrently with dendritic and axonal growth 
      and with myelination of the subcortical white matter. A phase of net synapse 
      elimination occurs late in childhood, earlier in auditory cortex, where it has 
      ended by age 12 years, than in prefrontal cortex, where it extends to 
      midadolescence. Synaptogenesis and synapse elimination in humans appear to be 
      heterochronous in different cortical regions and, in that respect, appears to 
      differ from the rhesus monkey, where they are concurrent. In other respects, 
      including overproduction of synaptic contacts in infancy, persistence of high 
      levels of synaptic density to late childhood or adolescence, the absolute values 
      of maximum and adult synaptic density, and layer specific differences, findings 
      in the human resemble those in rhesus monkeys.
FAU - Huttenlocher, P R
AU  - Huttenlocher PR
AD  - Department of Pediatrics, Committee on Neurobiology, University of Chicago, 
      Illinois 60637, USA. phutten@peds.bsd.uchicago.edu
FAU - Dabholkar, A S
AU  - Dabholkar AS
LA  - eng
GR  - 5RO1-NS28726/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
SB  - IM
MH  - Auditory Cortex/embryology/growth & development/*physiology
MH  - Brain Mapping/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Prefrontal Cortex/embryology/growth & development/*physiology
MH  - Synapses/*physiology
EDAT- 1997/10/23 22:34
MHDA- 2000/06/20 09:00
CRDT- 1997/10/23 22:34
PHST- 1997/10/23 22:34 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/10/23 22:34 [entrez]
AID - 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z [pii]
AID - 10.1002/(sici)1096-9861(19971020)387:2<167::aid-cne1>3.0.co;2-z [doi]
PST - ppublish
SO  - J Comp Neurol. 1997 Oct 20;387(2):167-78. doi: 
      10.1002/(sici)1096-9861(19971020)387:2<167::aid-cne1>3.0.co;2-z.