PMID- 9346952
OWN - NLM
STAT- MEDLINE
DCOM- 19971209
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 272
IP  - 44
DP  - 1997 Oct 31
TI  - Isolation and characterization of cDNAs corresponding to an additional member of 
      the human histone deacetylase gene family.
PG  - 28001-7
AB  - Several human cDNAs encoding a histone deacetylase protein, HDAC3, have been 
      isolated. Analysis of the predicted amino acid sequence of HDAC3 revealed an open 
      reading frame of 428 amino acids with a predicted molecular mass of 49 kDa. The 
      HDAC3 protein is 50% identical in DNA sequence and 53% identical in protein 
      sequence compared with the previously cloned human HDAC1. Comparison of the HDAC3 
      sequence with human HDAC2 also yielded similar results, with 51% identity in DNA 
      sequence and 52% identity in protein sequence. The expressed HDAC3 protein is 
      functionally active because it possesses histone deacetylase activity, represses 
      transcription when tethered to a promoter, and binds transcription factor YY1. 
      Similar to HDAC1 and HDAC2, HDAC3 is ubiquitously expressed in many different 
      cell types.
FAU - Yang, W M
AU  - Yang WM
AD  - Moffitt Cancer Center and Research Institute, the Department of Medical 
      Microbiology and Immunology, College of Medicine, University of South Florida, 
      Tampa, Florida 33612, USA.
FAU - Yao, Y L
AU  - Yao YL
FAU - Sun, J M
AU  - Sun JM
FAU - Davie, J R
AU  - Davie JR
FAU - Seto, E
AU  - Seto E
LA  - eng
SI  - GENBANK/AF005482
SI  - GENBANK/U75696
SI  - GENBANK/U75697
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 106388-42-5 (Peptide YY)
RN  - EC 3.5.1.98 (Histone Deacetylases)
RN  - EC 3.5.1.98 (histone deacetylase 3)
SB  - IM
MH  - Amino Acid Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - HeLa Cells
MH  - Histone Deacetylases/*genetics/metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Peptide YY/metabolism
MH  - Protein Binding
MH  - Sequence Homology, Amino Acid
EDAT- 1997/11/05 00:00
MHDA- 1997/11/05 00:01
CRDT- 1997/11/05 00:00
PHST- 1997/11/05 00:00 [pubmed]
PHST- 1997/11/05 00:01 [medline]
PHST- 1997/11/05 00:00 [entrez]
AID - S0021-9258(18)80357-X [pii]
AID - 10.1074/jbc.272.44.28001 [doi]
PST - ppublish
SO  - J Biol Chem. 1997 Oct 31;272(44):28001-7. doi: 10.1074/jbc.272.44.28001.