PMID- 9373256
OWN - NLM
STAT- MEDLINE
DCOM- 19971223
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 90
IP  - 11
DP  - 1997 Dec 1
TI  - E- and P-selectin are not involved in the recruitment of inflammatory cells 
      across the blood-brain barrier in experimental autoimmune encephalomyelitis.
PG  - 4459-72
AB  - In experimental autoimmune encephalomyelitis (EAE) inflammatory cells cross the 
      endothelial blood-brain barrier (BBB) and gain access to the central nervous 
      system (CNS). Here we show that E- and P-selectin are not involved in the 
      recruitment of inflammatory cells across the BBB. Neither expression of E- nor 
      P-selectin is induced in BBB-forming endothelium at any time after initiation of 
      EAE. Some of the inflammatory cells present in the CNS during EAE express ligands 
      for E- or P-selectin. However, anti-E- and P-selectin antibodies influence 
      neither immigration of inflammatory cells across the BBB nor the development of 
      EAE. In general, suppression of E- and P-selectin expression on BBB endothelium 
      is dependent on factors derived from the CNS microenvironment, eg, astrocytes. 
      Our results suggest that during EAE suppression of E- and P-selectin expression 
      on the BBB provides a CNS-specific mechanism to reduce leukocyte recruitment into 
      the CNS.
FAU - Engelhardt, B
AU  - Engelhardt B
AD  - Max-Planck Institut fur physiologische und klinische Forschung, W. G. 
      Kerckhoff-Institut, Bad Nauheim, Germany.
FAU - Vestweber, D
AU  - Vestweber D
FAU - Hallmann, R
AU  - Hallmann R
FAU - Schulz, M
AU  - Schulz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (E-Selectin)
RN  - 0 (P-Selectin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - *Blood-Brain Barrier
MH  - Capillaries/pathology
MH  - Cells, Cultured
MH  - Cerebrovascular Circulation
MH  - E-Selectin/analysis/*physiology
MH  - Encephalomyelitis, Autoimmune, Experimental/*pathology
MH  - Endothelium, Vascular/pathology
MH  - Female
MH  - Immune System/*pathology
MH  - Lymph Nodes/chemistry
MH  - Mice
MH  - Mice, Inbred Strains
MH  - P-Selectin/analysis/*physiology
MH  - RNA, Messenger/metabolism
MH  - Vascular Cell Adhesion Molecule-1/analysis
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - S0006-4971(20)56130-2 [pii]
PST - ppublish
SO  - Blood. 1997 Dec 1;90(11):4459-72.