PMID- 9393859
OWN - NLM
STAT- MEDLINE
DCOM- 19971229
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 91
IP  - 5
DP  - 1997 Nov 28
TI  - Identification of clonogenic common lymphoid progenitors in mouse bone marrow.
PG  - 661-72
AB  - The existence of a common lymphoid progenitor that can only give rise to T cells, 
      B cells, and natural killer (NK) cells remains controversial and constitutes an 
      important gap in the hematopoietic lineage maps. Here, we report that the 
      Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow 
      possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in 
      vivo but completely lacked myeloid differentiation potential either in vivo or in 
      vitro. A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at 
      least both T and B cells. These data provide direct evidence for the existence of 
      common lymphoid progenitors in sites of early hematopoiesis.
FAU - Kondo, M
AU  - Kondo M
AD  - Department of Pathology, Stanford University School of Medicine, California 
      94305, USA.
FAU - Weissman, I L
AU  - Weissman IL
FAU - Akashi, K
AU  - Akashi K
LA  - eng
GR  - CA42551/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Antigens, Ly)
RN  - 0 (Interleukin-7)
RN  - 0 (Ly6a protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Thy-1 Antigens)
RN  - 9004-67-5 (Methylcellulose)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Animals
MH  - Antigens, Ly/analysis
MH  - B-Lymphocytes/cytology
MH  - Cell Differentiation/physiology
MH  - Clone Cells/chemistry/cytology
MH  - Flow Cytometry
MH  - Hematopoietic Stem Cells/*chemistry/*cytology
MH  - Indicator Dilution Techniques
MH  - Interleukin-7/analysis
MH  - Membrane Proteins/analysis
MH  - Methylcellulose
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Proto-Oncogene Proteins c-kit/analysis
MH  - T-Lymphocytes/cytology
MH  - Thy-1 Antigens/analysis
EDAT- 1997/12/11 00:00
MHDA- 1997/12/11 00:01
CRDT- 1997/12/11 00:00
PHST- 1997/12/11 00:00 [pubmed]
PHST- 1997/12/11 00:01 [medline]
PHST- 1997/12/11 00:00 [entrez]
AID - S0092-8674(00)80453-5 [pii]
AID - 10.1016/s0092-8674(00)80453-5 [doi]
PST - ppublish
SO  - Cell. 1997 Nov 28;91(5):661-72. doi: 10.1016/s0092-8674(00)80453-5.