PMID- 9397021
OWN - NLM
STAT- MEDLINE
DCOM- 19971230
LR  - 20220408
IS  - 0006-8950 (Print)
IS  - 0006-8950 (Linking)
VI  - 120 ( Pt 11)
DP  - 1997 Nov
TI  - Comparison of MRI criteria at first presentation to predict conversion to 
      clinically definite multiple sclerosis.
PG  - 2059-69
AB  - We compared MRI criteria used to predict conversion of suspected multiple 
      sclerosis to clinically definite multiple sclerosis. Seventy-four patients with 
      clinically isolated neurological symptoms suggestive of multiple sclerosis were 
      studied with MRI. Logistic regression analysis was used to remove redundant 
      information, and a diagnostic model was built after each MRI parameter was 
      dichotomized according to maximum accuracy using receiver operating 
      characteristic analysis. Clinically definite multiple sclerosis developed in 33 
      patients (prevalence 45%). The optimum cut-off point (number of lesions) was one 
      for most MRI criteria (including gadolinium-enhancement and juxta-cortical 
      lesions), but three for periventricular lesions, and nine for the total number of 
      T2-lesions. Only gadolinium-enhancement and juxta-cortical lesions provided 
      independent information. A final model which, in addition, included 
      infratentorial and periventricular lesions, had an accuracy of 80%, and having 
      more abnormal criteria, predicted conversion to clinically definite multiple 
      sclerosis strongly. The model performed better than the criteria of Paty et al. 
      (Neurology 1988; 38: 180-5) and of Fazekas et al. (Neurology 1988; 38: 1822-5). 
      We concluded that a four-parameter dichotomized MRI model including 
      gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions 
      best predicts conversion to clinically definite multiple sclerosis.
FAU - Barkhof, F
AU  - Barkhof F
AD  - Department of Diagnostic Radiology, Vrije Universiteit Hospital, Amsterdam, The 
      Netherlands.
FAU - Filippi, M
AU  - Filippi M
FAU - Miller, D H
AU  - Miller DH
FAU - Scheltens, P
AU  - Scheltens P
FAU - Campi, A
AU  - Campi A
FAU - Polman, C H
AU  - Polman CH
FAU - Comi, G
AU  - Comi G
FAU - Ader, H J
AU  - Ader HJ
FAU - Losseff, N
AU  - Losseff N
FAU - Valk, J
AU  - Valk J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Brain
JT  - Brain : a journal of neurology
JID - 0372537
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Gadolinium
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Multiple Sclerosis/*diagnosis
MH  - Predictive Value of Tests
MH  - Time Factors
RF  - 41
EDAT- 1997/12/16 00:00
MHDA- 1997/12/16 00:01
CRDT- 1997/12/16 00:00
PHST- 1997/12/16 00:00 [pubmed]
PHST- 1997/12/16 00:01 [medline]
PHST- 1997/12/16 00:00 [entrez]
AID - 10.1093/brain/120.11.2059 [doi]
PST - ppublish
SO  - Brain. 1997 Nov;120 ( Pt 11):2059-69. doi: 10.1093/brain/120.11.2059.