PMID- 9419363
OWN - NLM
STAT- MEDLINE
DCOM- 19980218
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 95
IP  - 1
DP  - 1998 Jan 6
TI  - A chemokine expressed in lymphoid high endothelial venules promotes the adhesion 
      and chemotaxis of naive T lymphocytes.
PG  - 258-63
AB  - Preferential homing of naive lymphocytes to secondary lymphoid organs is thought 
      to involve the action of chemokines, yet no chemokine has been shown to have 
      either the expression pattern or the activities required to mediate this process. 
      Here we show that a chemokine represented in the EST database, secondary 
      lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of 
      lymph nodes and Peyer's patches, in the T cell areas of spleen, lymph nodes, and 
      Peyer's patches, and in the lymphatic endothelium of multiple organs. SLC is a 
      highly efficacious chemoattractant for lymphocytes with preferential activity 
      toward naive T cells. Moreover, SLC induces firm adhesion of naive T lymphocytes 
      via beta2 integrin binding to the counter receptor, intercellular adhesion 
      molecule-1, a necessary step for lymphocyte recruitment. SLC is the first 
      chemokine demonstrated to have the characteristics required to mediate homing of 
      lymphocytes to secondary lymphoid organs. In addition, the expression of SLC in 
      lymphatic endothelium suggests that the migration of lymphocytes from tissues 
      into efferent lymphatics may be an active process mediated by this molecule.
FAU - Gunn, M D
AU  - Gunn MD
AD  - Cardiovascular Research Institute, University of California, San Francisco, CA 
      94143, USA.
FAU - Tangemann, K
AU  - Tangemann K
FAU - Tam, C
AU  - Tam C
FAU - Cyster, J G
AU  - Cyster JG
FAU - Rosen, S D
AU  - Rosen SD
FAU - Williams, L T
AU  - Williams LT
LA  - eng
GR  - R37 GM023547/GM/NIGMS NIH HHS/United States
GR  - R37GM23547/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (CD18 Antigens)
RN  - 0 (Ccl21c protein, mouse)
RN  - 0 (Chemokine CCL21)
RN  - 0 (Chemokines, CC)
RN  - 0 (RNA, Messenger)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 42Z2K6ZL8P (Manganese)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Animals
MH  - CD18 Antigens/metabolism
MH  - Cell Adhesion/*drug effects
MH  - Chemokine CCL21
MH  - Chemokines, CC/metabolism/*pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Endothelium, Lymphatic/chemistry/*metabolism
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Manganese/metabolism
MH  - Mice
MH  - RNA, Messenger/metabolism
MH  - Sequence Analysis, DNA
MH  - T-Lymphocytes/cytology/*drug effects
MH  - Tetradecanoylphorbol Acetate/pharmacology
PMC - PMC18193
EDAT- 1998/02/21 00:00
MHDA- 1998/02/21 00:01
PMCR- 1998/07/06
CRDT- 1998/02/21 00:00
PHST- 1998/02/21 00:00 [pubmed]
PHST- 1998/02/21 00:01 [medline]
PHST- 1998/02/21 00:00 [entrez]
PHST- 1998/07/06 00:00 [pmc-release]
AID - 3817 [pii]
AID - 10.1073/pnas.95.1.258 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):258-63. doi: 10.1073/pnas.95.1.258.