PMID- 9428418
OWN - NLM
STAT- MEDLINE
DCOM- 19980202
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 124
IP  - 23
DP  - 1997 Dec
TI  - The Drosophila eyes absent gene directs ectopic eye formation in a pathway 
      conserved between flies and vertebrates.
PG  - 4819-26
AB  - The fly eyes absent (eya) gene which is essential for compound eye development in 
      Drosophila, was shown to be functionally replaceable in eye development by a 
      vertebrate Eya homolog. The relationship between eya and that of the eyeless 
      gene, a Pax-6 homolog, critical for eye formation in both flies and man, was 
      defined: eya was found to be essential for eye formation by eyeless. Moreover, 
      eya could itself direct ectopic eye formation, indicating that eya has the 
      capacity to function as a master control gene for eye formation. Finally, we show 
      that eya and eyeless together were more effective in eye formation than either 
      gene alone. These data indicate conservation of the pathway of eya function 
      between flies and vertebrates; they suggest a model whereby eya/Eya gene function 
      is essential for eye formation by eyeless/Pax-6, and that eya/Eya can in turn 
      mediate, via a regulatory loop, the activity of eyeless/Pax-6 in eye formation.
FAU - Bonini, N M
AU  - Bonini NM
AD  - Department of Biology, University of Pennsylvania, Philadelphia 19104-6018, USA. 
      nbonini@sas.upenn.edu
FAU - Bui, Q T
AU  - Bui QT
FAU - Gray-Board, G L
AU  - Gray-Board GL
FAU - Warrick, J M
AU  - Warrick JM
LA  - eng
GR  - EY11259/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (eya protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Drosophila/*genetics/growth & development
MH  - *Drosophila Proteins
MH  - Eye/*growth & development
MH  - Eye Proteins/*physiology
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - Mutation
MH  - Vertebrates/*genetics
EDAT- 1998/01/15 00:00
MHDA- 1998/01/15 00:01
CRDT- 1998/01/15 00:00
PHST- 1998/01/15 00:00 [pubmed]
PHST- 1998/01/15 00:01 [medline]
PHST- 1998/01/15 00:00 [entrez]
AID - 10.1242/dev.124.23.4819 [doi]
PST - ppublish
SO  - Development. 1997 Dec;124(23):4819-26. doi: 10.1242/dev.124.23.4819.