PMID- 9428513
OWN - NLM
STAT- MEDLINE
DCOM- 19980202
LR  - 20190816
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 91
IP  - 7
DP  - 1997 Dec 26
TI  - Dachshund and eyes absent proteins form a complex and function synergistically to 
      induce ectopic eye development in Drosophila.
PG  - 893-903
AB  - The eyeless, dachshund, and eyes absent genes encode conserved, nuclear proteins 
      that are essential for eye development in Drosophila. Misexpression of eyeless or 
      dachshund is also sufficient to induce the formation of ectopic compound eyes. 
      Here we show that the dachshund and eyes absent genes act synergistically to 
      induce ectopic retinal development and positively regulate the expression of each 
      other. Moreover, we show that the Dachshund and Eyes Absent proteins can 
      physically interact through conserved domains, suggesting a molecular basis for 
      the genetic synergy observed and that a similar complex may function in mammals. 
      We propose that a conserved regulatory network, rather than a linear hierarchy, 
      controls retinal specification and involves multiple protein complexes that 
      function during distinct steps of eye development.
FAU - Chen, R
AU  - Chen R
AD  - Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
FAU - Amoui, M
AU  - Amoui M
FAU - Zhang, Z
AU  - Zhang Z
FAU - Mardon, G
AU  - Mardon G
LA  - eng
GR  - EY07001/EY/NEI NIH HHS/United States
GR  - P30 HD24064/HD/NICHD NIH HHS/United States
GR  - R01 EY11232-01/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (dac protein, Drosophila)
RN  - 0 (eya protein, Drosophila)
SB  - IM
CIN - Cell. 1997 Dec 26;91(7):861-4. PMID: 9428507
MH  - Animals
MH  - Cell Differentiation
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Drug Synergism
MH  - Eye Proteins/genetics/*physiology
MH  - Insect Proteins/genetics/*physiology
MH  - Nuclear Proteins/genetics/*physiology
MH  - Photoreceptor Cells, Invertebrate/*embryology
MH  - Protein Binding
MH  - Retina/embryology/growth & development
MH  - Transcription, Genetic
EDAT- 1998/01/15 00:00
MHDA- 1998/01/15 00:01
CRDT- 1998/01/15 00:00
PHST- 1998/01/15 00:00 [pubmed]
PHST- 1998/01/15 00:01 [medline]
PHST- 1998/01/15 00:00 [entrez]
AID - S0092-8674(00)80481-X [pii]
AID - 10.1016/s0092-8674(00)80481-x [doi]
PST - ppublish
SO  - Cell. 1997 Dec 26;91(7):893-903. doi: 10.1016/s0092-8674(00)80481-x.