PMID- 9428514
OWN - NLM
STAT- MEDLINE
DCOM- 19980202
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 91
IP  - 7
DP  - 1997 Dec 26
TI  - The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell 
      shape changes in Drosophila gastrulation.
PG  - 905-15
AB  - The Rho GTPases mediate actin rearrangements that are likely to be required for 
      the numerous cell shape changes in a developing embryo. In a genetic screen for 
      Rho signaling pathway components in Drosophila, we identified a gene, DRhoGEF2, 
      that encodes a predicted Rho-specific guanine nucleotide exchange factor. Embryos 
      lacking DRhoGEF2 fail to gastrulate due to a defect in cell shape changes 
      required for tissue invagination, and expression of a dominant-negative Rho 
      GTPase in early embryos results in similar defects. Evidence is also presented 
      that DRhoGEF2 mediates these specific cell shape changes in response to the 
      extracellular ligand, Fog. Together, these results establish a Rho-mediated 
      signaling pathway that is essential for the major morphogenetic events in 
      Drosophila gastrulation.
FAU - Barrett, K
AU  - Barrett K
AD  - Massachusetts General Hospital Cancer Center and Harvard Medical School, 
      Charlestown 02129, USA.
FAU - Leptin, M
AU  - Leptin M
FAU - Settleman, J
AU  - Settleman J
LA  - eng
SI  - GENBANK/AF032870
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Proteins)
RN  - 0 (rho GTPase-activating protein)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (Rho1 protein, Drosophila)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Size/physiology
MH  - Cloning, Molecular
MH  - Drosophila/embryology
MH  - Drosophila Proteins
MH  - GTP Phosphohydrolases/*physiology
MH  - GTP-Binding Proteins/*physiology
MH  - *GTPase-Activating Proteins
MH  - Gastrula/*cytology/physiology
MH  - Guanine Nucleotide Exchange Factors
MH  - Humans
MH  - Molecular Sequence Data
MH  - Morphogenesis/genetics
MH  - Proteins/genetics/*physiology
MH  - *Signal Transduction
MH  - *rho GTP-Binding Proteins
EDAT- 1998/01/15 00:00
MHDA- 1998/01/15 00:01
CRDT- 1998/01/15 00:00
PHST- 1998/01/15 00:00 [pubmed]
PHST- 1998/01/15 00:01 [medline]
PHST- 1998/01/15 00:00 [entrez]
AID - S0092-8674(00)80482-1 [pii]
AID - 10.1016/s0092-8674(00)80482-1 [doi]
PST - ppublish
SO  - Cell. 1997 Dec 26;91(7):905-15. doi: 10.1016/s0092-8674(00)80482-1.