PMID- 9430587
OWN - NLM
STAT- MEDLINE
DCOM- 19980202
LR  - 20220331
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 279
IP  - 5349
DP  - 1998 Jan 16
TI  - Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model.
PG  - 377-80
AB  - In vivo selection of phage display libraries was used to isolate peptides that 
      home specifically to tumor blood vessels. When coupled to the anticancer drug 
      doxorubicin, two of these peptides-one containing an alphav integrin-binding 
      Arg-Gly-Asp motif and the other an Asn-Gly-Arg motif-enhanced the efficacy of the 
      drug against human breast cancer xenografts in nude mice and also reduced its 
      toxicity. These results indicate that it may be possible to develop targeted 
      chemotherapy strategies that are based on selective expression of receptors in 
      tumor vasculature.
FAU - Arap, W
AU  - Arap W
AD  - Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La 
      Jolla, CA 92037, USA.
FAU - Pasqualini, R
AU  - Pasqualini R
FAU - Ruoslahti, E
AU  - Ruoslahti E
LA  - eng
GR  - CA30199/CA/NCI NIH HHS/United States
GR  - CA62042/CA/NCI NIH HHS/United States
GR  - CA74238-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Integrin alphaV)
RN  - 0 (Integrins)
RN  - 0 (Oligopeptides)
RN  - 0 (Peptide Library)
RN  - 0 (doxorubicin cysteinyl-asparagyl-glycyl-arginyl-cysteine conjugate)
RN  - 0 (doxorubucin 
      cysteinyl-aspartyl-cysteinyl-arginyl-glycyl-aspartyl-cycsteinyl-phenylalanyl-cysteine 
      conjugate)
RN  - 80168379AG (Doxorubicin)
SB  - IM
CIN - Science. 1998 Jan 16;279(5349):323-4. PMID: 9454325
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Antineoplastic Agents/*administration & dosage/therapeutic use/toxicity
MH  - Bacteriophages
MH  - Coronary Vessels/drug effects
MH  - Doxorubicin/*administration & dosage/*analogs & 
      derivatives/metabolism/therapeutic use/toxicity
MH  - *Drug Carriers
MH  - Heart/drug effects
MH  - Humans
MH  - Integrin alphaV
MH  - Integrins/metabolism
MH  - Liver/blood supply/drug effects
MH  - Mice
MH  - Mice, Nude
MH  - Neoplasm Transplantation
MH  - Neoplasms, Experimental/*blood supply/*drug therapy/pathology
MH  - Oligopeptides/*administration & dosage/metabolism/therapeutic use/toxicity
MH  - Peptide Library
MH  - Random Allocation
MH  - Transplantation, Heterologous
MH  - Tumor Cells, Cultured
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - 10.1126/science.279.5349.377 [doi]
PST - ppublish
SO  - Science. 1998 Jan 16;279(5349):377-80. doi: 10.1126/science.279.5349.377.