PMID- 9466541
OWN - NLM
STAT- MEDLINE
DCOM- 19980306
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 177
IP  - 2
DP  - 1998 Feb
TI  - High human immunodeficiency virus type 1 RNA load in the cerebrospinal fluid from 
      patients with lymphocytic meningitis.
PG  - 473-6
AB  - Thirty-seven matched cerebrospinal fluid (CSF) and plasma samples from 34 human 
      immunodeficiency virus type 1 (HIV-1)-infected patients with suspected meningitis 
      were analyzed for levels of HIV-1 RNA and markers of inflammation. Patients with 
      tuberculous (n = 9) or cryptococcal (n = 6) meningitis had the highest CSF virus 
      loads, which in many cases exceeded the levels in plasma, compared with patients 
      with meningococcal meningitis (n = 3), aseptic meningitis (n = 8), tuberculoma (n 
      = 2), or AIDS dementia complex (n = 4) or with normal lumbar punctures (n = 3). 
      CSF virus load correlated significantly with the number of infiltrating 
      lymphocytes (r = .60, P < .001) but not with plasma virus load, the levels of 
      beta2-microglobulin in the CSF, or the integrity of the blood-brain barrier. 
      These data suggest significant intrathecal HIV-1 replication in patients with 
      lymphocytic meningeal infections such as tuberculous and cryptococcal meningitis.
FAU - Morris, L
AU  - Morris L
AD  - National Institute for Virology, Department of Virology, University of the 
      Witwatersrand, Johannesburg, South Africa. lmorris@adarc.org
FAU - Silber, E
AU  - Silber E
FAU - Sonnenberg, P
AU  - Sonnenberg P
FAU - Eintracht, S
AU  - Eintracht S
FAU - Nyoka, S
AU  - Nyoka S
FAU - Lyons, S F
AU  - Lyons SF
FAU - Saffer, D
AU  - Saffer D
FAU - Koornhof, H
AU  - Koornhof H
FAU - Martin, D J
AU  - Martin DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HIV Core Protein p24)
RN  - 0 (RNA, Viral)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - AIDS Dementia Complex/blood/cerebrospinal fluid/immunology
MH  - Blood-Brain Barrier
MH  - CD4 Lymphocyte Count
MH  - Cryptococcosis/blood/cerebrospinal fluid/immunology
MH  - HIV Core Protein p24/analysis
MH  - HIV Infections/blood/*cerebrospinal fluid/immunology
MH  - HIV-1/genetics/*isolation & purification
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocytes/immunology
MH  - Meningitis/blood/*cerebrospinal fluid/*virology
MH  - Meningitis, Aseptic/blood/cerebrospinal fluid/immunology
MH  - Meningitis, Fungal/blood/cerebrospinal fluid/immunology
MH  - Meningitis, Meningococcal/blood/cerebrospinal fluid/immunology
MH  - RNA, Viral/analysis/*isolation & purification
MH  - Tuberculosis, Meningeal/blood/cerebrospinal fluid/immunology
MH  - Viral Load
MH  - beta 2-Microglobulin/analysis/metabolism
EDAT- 1998/02/18 00:00
MHDA- 1998/02/18 00:01
CRDT- 1998/02/18 00:00
PHST- 1998/02/18 00:00 [pubmed]
PHST- 1998/02/18 00:01 [medline]
PHST- 1998/02/18 00:00 [entrez]
AID - 10.1086/517379 [doi]
PST - ppublish
SO  - J Infect Dis. 1998 Feb;177(2):473-6. doi: 10.1086/517379.