PMID- 9488663
OWN - NLM
STAT- MEDLINE
DCOM- 19980407
LR  - 20220225
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 273
IP  - 10
DP  - 1998 Mar 6
TI  - Identification of Nore1 as a potential Ras effector.
PG  - 5439-42
AB  - The small GTP-binding protein Ras is pivotal in transmitting growth and 
      differentiation signals downstream of cell surface receptors. Many observations 
      have indicated that Ras transmits signals from cell surface receptors into 
      multiple pathways via direct interaction with different effectors in mammalian 
      cells. We have identified a novel potential Ras effector or target named Nore1. 
      Nore1 has no significant sequence similarity to known mammalian proteins and 
      lacks an identifiable catalytic domain, but contains sequence motifs that predict 
      DAG_PE binding and SH3 domain binding. We show that Nore1 directly interacts with 
      Ras in vitro in a GTP-dependent manner, and the interaction requires an intact 
      Ras effector domain. Nore1 becomes associated with Ras in situ following 
      activation of epidermal growth factor receptor in COS-7 and in KB cells.
FAU - Vavvas, D
AU  - Vavvas D
AD  - The Diabetes Unit and Medical Services and the Department of Medicine, Harvard 
      Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts 
      02129, USA.
FAU - Li, X
AU  - Li X
FAU - Avruch, J
AU  - Avruch J
FAU - Zhang, X F
AU  - Zhang XF
LA  - eng
SI  - GENBANK/AF053959
GR  - GM51281/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nr4a3 protein, mouse)
RN  - 0 (Nr4a3 protein, rat)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (ras Proteins)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*chemistry/physiology
MH  - Epidermal Growth Factor/pharmacology
MH  - GTP-Binding Proteins/*chemistry/physiology
MH  - Gene Expression Regulation/genetics
MH  - Guanosine Triphosphate/pharmacology
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Nuclear Proteins/*chemistry/physiology
MH  - Protein Binding/physiology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Receptors, Steroid
MH  - Receptors, Thyroid Hormone
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - ras Proteins/*metabolism
EDAT- 1998/04/16 00:00
MHDA- 1998/04/16 00:01
CRDT- 1998/04/16 00:00
PHST- 1998/04/16 00:00 [pubmed]
PHST- 1998/04/16 00:01 [medline]
PHST- 1998/04/16 00:00 [entrez]
AID - S0021-9258(18)67791-9 [pii]
AID - 10.1074/jbc.273.10.5439 [doi]
PST - ppublish
SO  - J Biol Chem. 1998 Mar 6;273(10):5439-42. doi: 10.1074/jbc.273.10.5439.