PMID- 9495550
OWN - NLM
STAT- MEDLINE
DCOM- 19980504
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 52
IP  - 2
DP  - 1997 Dec 15
TI  - Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA 
      amount in human brain with aging.
PG  - 284-9
AB  - The contribution of the mitochondrial genetic system in the degenerative 
      processes of senescence remains unclear. This study deals with age-related 
      changes in brain mtDNA expression in humans. Brain tissue from the frontal lobe 
      cortex was obtained from autopsy of 13 humans aged between 21 and 84 years. No 
      structural changes were detected in mtDNA, increased mtDNA content and reduced 
      steady-state level of mitochondrial transcripts and transcription ratio 
      (mtRNA/mtDNA) were associated with aging. These findings suggest that the 
      increase of the mtDNA levels could be considered as an inefficient compensatory 
      mechanism to maintain the normal levels of mtRNA transcripts. This unbalanced 
      mitochondrial condition could play a role in the process of senescence in human 
      brain.
FAU - Barrientos, A
AU  - Barrientos A
AD  - Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain.
FAU - Casademont, J
AU  - Casademont J
FAU - Cardellach, F
AU  - Cardellach F
FAU - Estivill, X
AU  - Estivill X
FAU - Urbano-Marquez, A
AU  - Urbano-Marquez A
FAU - Nunes, V
AU  - Nunes V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (DNA, Ribosomal)
RN  - 0 (RNA, Mitochondrial)
RN  - 0 (RNA, Ribosomal, 18S)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - DNA, Mitochondrial/analysis/*metabolism
MH  - DNA, Ribosomal/metabolism
MH  - Frontal Lobe/growth & development/*metabolism
MH  - Humans
MH  - Middle Aged
MH  - RNA/*metabolism
MH  - RNA, Mitochondrial
MH  - RNA, Ribosomal, 18S/genetics
MH  - Reference Values
MH  - Regression Analysis
MH  - Transcription, Genetic
EDAT- 1998/03/12 00:00
MHDA- 1998/03/12 00:01
CRDT- 1998/03/12 00:00
PHST- 1998/03/12 00:00 [pubmed]
PHST- 1998/03/12 00:01 [medline]
PHST- 1998/03/12 00:00 [entrez]
AID - S0169328X97002787 [pii]
AID - 10.1016/s0169-328x(97)00278-7 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1997 Dec 15;52(2):284-9. doi: 
      10.1016/s0169-328x(97)00278-7.