PMID- 9498303
OWN - NLM
STAT- MEDLINE
DCOM- 19980429
LR  - 20190914
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 21
IP  - 2
DP  - 1998 Feb
TI  - Matrix metalloproteinases and diseases of the CNS.
PG  - 75-80
AB  - Matrix metalloproteinases (MMPs) are increasingly being implicated in the 
      pathogenesis of several CNS diseases. In multiple sclerosis, MMPs could be 
      responsible for the influx of inflammatory mononuclear cells into the CNS, 
      contribute to myelin destruction and disrupt the integrity of the blood-brain 
      barrier; in Alzheimer's disease, MMPs might mediate the deposition of amyloid 
      beta-proteins; and MMPs are known to contribute to the invasiveness of malignant 
      glioma cells and might regulate their angiogenic capacity. Nonetheless, MMPs 
      could also have beneficial roles in recovery from CNS injury.Therefore, both the 
      identity of the MMP and its cellular origin could determine whether disease 
      pathogenesis or regeneration occurs, and thus synthetic MMP inhibitors might be 
      valuable for treating some CNS diseases.
FAU - Yong, V W
AU  - Yong VW
AD  - Dept of Oncology, University of Calgary, Alberta, Canada.
FAU - Krekoski, C A
AU  - Krekoski CA
FAU - Forsyth, P A
AU  - Forsyth PA
FAU - Bell, R
AU  - Bell R
FAU - Edwards, D R
AU  - Edwards DR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
CIN - Trends Neurosci. 2001 Jan;24(1):8-9. PMID: 11261939
MH  - Animals
MH  - Central Nervous System Diseases/*enzymology/pathology
MH  - Extracellular Matrix/*enzymology
MH  - Humans
MH  - Metalloendopeptidases/*metabolism
RF  - 50
EDAT- 1998/03/14 00:00
MHDA- 1998/03/14 00:01
CRDT- 1998/03/14 00:00
PHST- 1998/03/14 00:00 [pubmed]
PHST- 1998/03/14 00:01 [medline]
PHST- 1998/03/14 00:00 [entrez]
AID - S0166223697011697 [pii]
AID - 10.1016/s0166-2236(97)01169-7 [doi]
PST - ppublish
SO  - Trends Neurosci. 1998 Feb;21(2):75-80. doi: 10.1016/s0166-2236(97)01169-7.