PMID- 9515965
OWN - NLM
STAT- MEDLINE
DCOM- 19980326
LR  - 20220225
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 392
IP  - 6672
DP  - 1998 Mar 12
TI  - A causal role for E-cadherin in the transition from adenoma to carcinoma.
PG  - 190-3
AB  - Development of malignant tumours is in part characterized by the ability of a 
      tumour cell to overcome cell-cell adhesion and to invade surrounding tissue. 
      E-cadherin is the main adhesion molecule of epithelia, and it has been implicated 
      in carcinogenesis because it is frequently lost in human epithelial cancers. 
      Re-establishing the functional cadherin complex in tumour cell lines results in a 
      reversion from an invasive to a benign epithelial phenotype. However, it remained 
      unresolved whether the loss of E-cadherin-mediated cell adhesion was a cause or a 
      consequence of tumour progression in vivo. Here we report that the loss of 
      E-cadherin expression coincides with the transition from well differentiated 
      adenoma to invasive carcinoma in a transgenic mouse model of pancreatic beta-cell 
      carcinogenesis (Rip1Tag2). Intercrossing Rip1Tag2 mice with transgenic mice that 
      maintain E-cadherin expression in beta-tumour cells results in arrest of tumour 
      development at the adenoma stage, whereas expression of a dominant-negative form 
      of E-cadherin induces early invasion and metastasis. The results demonstrate that 
      loss of E-cadherin-mediated cell adhesion is one rate-limiting step in the 
      progression from adenoma to carcinoma.
FAU - Perl, A K
AU  - Perl AK
AD  - Research Institute of Molecular Pathology, Vienna, Austria.
FAU - Wilgenbus, P
AU  - Wilgenbus P
FAU - Dahl, U
AU  - Dahl U
FAU - Semb, H
AU  - Semb H
FAU - Christofori, G
AU  - Christofori G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Cadherins)
SB  - IM
MH  - Adenoma, Islet Cell/*pathology
MH  - Animals
MH  - Cadherins/biosynthesis/*physiology
MH  - Carcinoma, Islet Cell/*etiology/pathology/secondary
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - *Islets of Langerhans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neoplasm Invasiveness
MH  - Pancreatic Neoplasms/*etiology/pathology
EDAT- 1998/03/27 03:03
MHDA- 2001/03/23 10:01
CRDT- 1998/03/27 03:03
PHST- 1998/03/27 03:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1998/03/27 03:03 [entrez]
AID - 10.1038/32433 [doi]
PST - ppublish
SO  - Nature. 1998 Mar 12;392(6672):190-3. doi: 10.1038/32433.