PMID- 9521319
OWN - NLM
STAT- MEDLINE
DCOM- 19980406
LR  - 20240109
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 392
IP  - 6673
DP  - 1998 Mar 19
TI  - Dendritic cells and the control of immunity.
PG  - 245-52
AB  - B and T lymphocytes are the mediators of immunity, but their function is under 
      the control of dendritic cells. Dendritic cells in the periphery capture and 
      process antigens, express lymphocyte co-stimulatory molecules, migrate to 
      lymphoid organs and secrete cytokines to initiate immune responses. They not only 
      activate lymphocytes, they also tolerize T cells to antigens that are innate to 
      the body (self-antigens), thereby minimizing autoimmune reactions. Once a 
      neglected cell type, dendritic cells can now be readily obtained in sufficient 
      quantities to allow molecular and cell biological analysis. With knowledge comes 
      the realization that these cells are a powerful tool for manipulating the immune 
      system.
FAU - Banchereau, J
AU  - Banchereau J
AD  - Baylor Institute for Immunology, Research, Baylor Research Institute, Dallas, 
      Texas 75246, USA.
FAU - Steinman, R M
AU  - Steinman RM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - B-Lymphocytes/immunology
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Dendritic Cells/cytology/*immunology
MH  - Forecasting
MH  - Humans
MH  - Immunity/*physiology
MH  - Self Tolerance/immunology
MH  - T-Lymphocytes/immunology
RF  - 103
EDAT- 1998/04/01 03:03
MHDA- 2001/03/23 10:01
CRDT- 1998/04/01 03:03
PHST- 1998/04/01 03:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1998/04/01 03:03 [entrez]
AID - 10.1038/32588 [doi]
PST - ppublish
SO  - Nature. 1998 Mar 19;392(6673):245-52. doi: 10.1038/32588.