PMID- 9545219
OWN - NLM
STAT- MEDLINE
DCOM- 19980507
LR  - 20220321
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 280
IP  - 5362
DP  - 1998 Apr 17
TI  - Gastrointestinal tract as a major site of CD4+ T cell depletion and viral 
      replication in SIV infection.
PG  - 427-31
AB  - Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in 
      activated memory CD4(+) T cells, a cell type that is abundant in the intestine. 
      SIV infection of rhesus monkeys resulted in profound and selective depletion of 
      CD4+ T cells in the intestine within days of infection, before any such changes 
      in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine 
      occurred coincident with productive infection of large numbers of mononuclear 
      cells at this site. The intestine appears to be a major target for SIV 
      replication and the major site of CD4+ T cell loss in early SIV infection.
FAU - Veazey, R S
AU  - Veazey RS
AD  - New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill 
      Drive, Post Office Box 9102, Southborough, MA 01772, USA.
FAU - DeMaria, M
AU  - DeMaria M
FAU - Chalifoux, L V
AU  - Chalifoux LV
FAU - Shvetz, D E
AU  - Shvetz DE
FAU - Pauley, D R
AU  - Pauley DR
FAU - Knight, H L
AU  - Knight HL
FAU - Rosenzweig, M
AU  - Rosenzweig M
FAU - Johnson, R P
AU  - Johnson RP
FAU - Desrosiers, R C
AU  - Desrosiers RC
FAU - Lackner, A A
AU  - Lackner AA
LA  - eng
GR  - AI25328/AI/NIAID NIH HHS/United States
GR  - AI38559/AI/NIAID NIH HHS/United States
GR  - DK50550/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Animals
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/*immunology/virology
MH  - Colon/*immunology/virology
MH  - Immunity, Mucosal
MH  - Immunologic Memory
MH  - Intestinal Mucosa/immunology/virology
MH  - Intestine, Small/*immunology/virology
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology/virology
MH  - Lymphoid Tissue/immunology/virology
MH  - Macaca mulatta
MH  - Macrophages/virology
MH  - Male
MH  - Receptors, Interleukin-2/analysis
MH  - Simian Acquired Immunodeficiency Syndrome/*immunology/*virology
MH  - Simian Immunodeficiency Virus/immunology/pathogenicity/*physiology
MH  - Viral Load
MH  - Virulence
MH  - Virus Replication
EDAT- 1998/05/09 00:00
MHDA- 1998/05/09 00:01
CRDT- 1998/05/09 00:00
PHST- 1998/05/09 00:00 [pubmed]
PHST- 1998/05/09 00:01 [medline]
PHST- 1998/05/09 00:00 [entrez]
AID - 10.1126/science.280.5362.427 [doi]
PST - ppublish
SO  - Science. 1998 Apr 17;280(5362):427-31. doi: 10.1126/science.280.5362.427.