PMID- 9619120
OWN - NLM
STAT- MEDLINE
DCOM- 19980629
LR  - 20230120
IS  - 0032-0943 (Print)
IS  - 0032-0943 (Linking)
VI  - 64
IP  - 4
DP  - 1998 May
TI  - Influence of piperine on the pharmacokinetics of curcumin in animals and human 
      volunteers.
PG  - 353-6
AB  - The medicinal properties of curcumin obtained from Curcuma longa L. cannot be 
      utilised because of poor bioavailability due to its rapid metabolism in the liver 
      and intestinal wall. In this study, the effect of combining piperine, a known 
      inhibitor of hepatic and intestinal glucuronidation, was evaluated on the 
      bioavailability of curcumin in rats and healthy human volunteers. When curcumin 
      was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were 
      achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg 
      increased the serum concentration of curcumin for a short period of 1-2 h post 
      drug. Time to maximum was significantly increased (P < 0.02) while elimination 
      half life and clearance significantly decreased (P < 0.02), and the 
      bioavailability was increased by 154%. On the other hand in humans after a dose 
      of 2 g curcumin alone, serum levels were either undetectable or very low. 
      Concomitant administration of piperine 20 mg produced much higher concentrations 
      from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the 
      increase in bioavailability was 2000%. The study shows that in the dosages used, 
      piperine enhances the serum concentration, extent of absorption and 
      bioavailability of curcumin in both rats and humans with no adverse effects.
FAU - Shoba, G
AU  - Shoba G
AD  - Department of Pharmacology, St. John's Medical College, Bangalore, India.
FAU - Joy, D
AU  - Joy D
FAU - Joseph, T
AU  - Joseph T
FAU - Majeed, M
AU  - Majeed M
FAU - Rajendran, R
AU  - Rajendran R
FAU - Srinivas, P S
AU  - Srinivas PS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Alkaloids)
RN  - 0 (Benzodioxoles)
RN  - 0 (Piperidines)
RN  - 0 (Polyunsaturated Alkamides)
RN  - IT942ZTH98 (Curcumin)
RN  - U71XL721QK (piperine)
SB  - IM
MH  - Adult
MH  - *Alkaloids
MH  - Animals
MH  - Area Under Curve
MH  - Benzodioxoles
MH  - Chromatography, High Pressure Liquid
MH  - Curcumin/*pharmacokinetics
MH  - Drug Interactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Piperidines/*pharmacology
MH  - Polyunsaturated Alkamides
MH  - Rats
MH  - Rats, Wistar
MH  - Spectrophotometry, Ultraviolet
EDAT- 1998/06/10 00:00
MHDA- 1998/06/10 00:01
CRDT- 1998/06/10 00:00
PHST- 1998/06/10 00:00 [pubmed]
PHST- 1998/06/10 00:01 [medline]
PHST- 1998/06/10 00:00 [entrez]
AID - 10.1055/s-2006-957450 [doi]
PST - ppublish
SO  - Planta Med. 1998 May;64(4):353-6. doi: 10.1055/s-2006-957450.