PMID- 9748157 OWN - NLM STAT- MEDLINE DCOM- 19981008 LR - 20190619 IS - 0036-8075 (Print) IS - 0036-8075 (Linking) VI - 281 IP - 5385 DP - 1998 Sep 25 TI - Semiconductor nanocrystals as fluorescent biological labels. PG - 2013-6 AB - Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores. FAU - Bruchez, M Jr AU - Bruchez M Jr AD - Department of Chemistry, University of California, Berkeley, CA 94720, USA. FAU - Moronne, M AU - Moronne M FAU - Gin, P AU - Gin P FAU - Weiss, S AU - Weiss S FAU - Alivisatos, A P AU - Alivisatos AP LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Science JT - Science (New York, N.Y.) JID - 0404511 RN - 0 (Actins) RN - 0 (Cadmium Compounds) RN - 0 (Fluorescent Dyes) RN - 0 (Selenium Compounds) RN - 0 (Sulfides) RN - 057EZR4Z7Q (cadmium sulfide) RN - 7631-86-9 (Silicon Dioxide) RN - A7F646JC5C (cadmium selenide) SB - IM CIN - Science. 1998 Sep 25;281(5385):1930-1. PMID: 9767032 MH - 3T3 Cells MH - Actins MH - Animals MH - Biotinylation MH - *Cadmium Compounds MH - Cell Nucleus/*ultrastructure MH - Crystallization MH - Cytoskeleton/*ultrastructure MH - *Fluorescent Dyes MH - Mice MH - Microscopy, Confocal MH - Microscopy, Fluorescence MH - Molecular Probe Techniques MH - *Selenium Compounds MH - *Semiconductors MH - Silicon Dioxide MH - Solubility MH - Spectrometry, Fluorescence MH - Staining and Labeling/methods MH - *Sulfides EDAT- 1998/09/25 02:03 MHDA- 2001/03/28 10:01 CRDT- 1998/09/25 02:03 PHST- 1998/09/25 02:03 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1998/09/25 02:03 [entrez] AID - 10.1126/science.281.5385.2013 [doi] PST - ppublish SO - Science. 1998 Sep 25;281(5385):2013-6. doi: 10.1126/science.281.5385.2013.