PMID- 9776860
OWN - NLM
STAT- MEDLINE
DCOM- 19990114
LR  - 20220410
IS  - 1067-1927 (Print)
IS  - 1067-1927 (Linking)
VI  - 6
IP  - 2
DP  - 1998 Mar-Apr
TI  - Enhancement of wound healing by curcumin in animals.
PG  - 167-77
AB  - Tissue repair and wound healing are complex processes that involve inflammation, 
      granulation, and remodeling of the tissue. In this study, we evaluated the in 
      vivo effects of curcumin (difeurloylmethane), a natural product obtained from the 
      rhizomes of Curcuma longa on wound healing in rats and guinea pigs. We observed 
      faster wound closure of punch wounds in curcumin-treated animals in comparison 
      with untreated controls. Biopsies of the wound showed reepithelialization of the 
      epidermis and increased migration of various cells including myofibroblasts, 
      fibroblasts, and macrophages in the wound bed. Multiple areas within the dermis 
      showed extensive neovascularization, and Masson's Trichrome staining showed 
      greater collagen deposition in curcumin-treated wounds. Immunohistochemical 
      localization of transforming growth factor-beta1 showed an increase in 
      curcumin-treated wounds as compared with untreated wounds. In situ hybridization 
      and polymerase chain reaction analysis also showed an increase in the mRNA 
      transcripts of transforming growth factor-beta1 and fibronectin in 
      curcumin-treated wounds. Because transforming growth factor-beta1 is known to 
      enhance wound healing, it may be possible that transforming growth factor-beta1 
      plays an important role in the enhancement of wound healing by curcumin.
FAU - Sidhu, G S
AU  - Sidhu GS
AD  - Center for Combat Casualty and Life Sustainment Research, Department of 
      Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 
      USA.
FAU - Singh, A K
AU  - Singh AK
FAU - Thaloor, D
AU  - Thaloor D
FAU - Banaudha, K K
AU  - Banaudha KK
FAU - Patnaik, G K
AU  - Patnaik GK
FAU - Srimal, R C
AU  - Srimal RC
FAU - Maheshwari, R K
AU  - Maheshwari RK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Wound Repair Regen
JT  - Wound repair and regeneration : official publication of the Wound Healing Society 
      [and] the European Tissue Repair Society
JID - 9310939
RN  - 0 (Actins)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Transforming Growth Factor beta)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Actins/analysis/*biosynthesis
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Culture Techniques
MH  - Curcumin/*metabolism/pharmacology
MH  - Disease Models, Animal
MH  - Guinea Pigs
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Skin/drug effects/injuries/*metabolism/pathology
MH  - Transforming Growth Factor beta/analysis/*biosynthesis
MH  - Wound Healing/drug effects/*physiology
MH  - Wounds, Penetrating/*physiopathology
EDAT- 1998/10/20 00:00
MHDA- 1998/10/20 00:01
CRDT- 1998/10/20 00:00
PHST- 1998/10/20 00:00 [pubmed]
PHST- 1998/10/20 00:01 [medline]
PHST- 1998/10/20 00:00 [entrez]
AID - 10.1046/j.1524-475x.1998.60211.x [doi]
PST - ppublish
SO  - Wound Repair Regen. 1998 Mar-Apr;6(2):167-77. doi: 
      10.1046/j.1524-475x.1998.60211.x.