PMID- 9784499
OWN - NLM
STAT- MEDLINE
DCOM- 19981130
LR  - 20190606
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 12
IP  - 20
DP  - 1998 Oct 15
TI  - Drosophila unpaired encodes a secreted protein that activates the JAK signaling 
      pathway.
PG  - 3252-63
AB  - In vertebrates, many cytokines and growth factors have been identified as 
      activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT 
      molecules have been isolated, but no ligands or receptors capable of activating 
      the pathway have been described. We have characterized the unpaired (upd) gene, 
      which displays the same distinctive embryonic mutant defects as mutations in the 
      Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, 
      associated with the extracellular matrix, that activates the JAK pathway. We 
      propose that Upd is a ligand that relies on JAK signaling to stimulate 
      transcription of pair-rule genes in a segmentally restricted manner in the early 
      Drosophila embryo.
FAU - Harrison, D A
AU  - Harrison DA
AD  - Department of Genetics, Boston, Massachusetts 02115 USA. DougH@pop.uky.edu
FAU - McCoon, P E
AU  - McCoon PE
FAU - Binari, R
AU  - Binari R
FAU - Gilman, M
AU  - Gilman M
FAU - Perrimon, N
AU  - Perrimon N
LA  - eng
SI  - GENBANK/AF072823
GR  - CA45642/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Insect Proteins)
RN  - 0 (STAT Transcription Factors)
RN  - 0 (Stat92E protein, Drosophila)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (sr protein, Drosophila)
RN  - 0 (upd1 protein, Drosophila)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 2.7.10.2 (hop protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Pairing
MH  - Base Sequence
MH  - Cytokines/physiology
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Embryo, Nonmammalian/metabolism
MH  - Extracellular Matrix Proteins/chemistry
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Insect/genetics
MH  - Glycoproteins/chemistry/*genetics/metabolism
MH  - Insect Proteins/genetics/metabolism/*physiology
MH  - Janus Kinases
MH  - Molecular Sequence Data
MH  - Protein-Tyrosine Kinases/genetics/metabolism/physiology
MH  - Receptor Protein-Tyrosine Kinases/*metabolism/physiology
MH  - STAT Transcription Factors
MH  - Signal Transduction/*physiology
MH  - Trans-Activators/genetics
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
PMC - PMC317220
EDAT- 1998/10/24 00:00
MHDA- 1998/10/24 00:01
PMCR- 1999/04/15
CRDT- 1998/10/24 00:00
PHST- 1998/10/24 00:00 [pubmed]
PHST- 1998/10/24 00:01 [medline]
PHST- 1998/10/24 00:00 [entrez]
PHST- 1999/04/15 00:00 [pmc-release]
AID - 10.1101/gad.12.20.3252 [doi]
PST - ppublish
SO  - Genes Dev. 1998 Oct 15;12(20):3252-63. doi: 10.1101/gad.12.20.3252.