PMID- 9808159
OWN - NLM
STAT- MEDLINE
DCOM- 19981119
LR  - 20211203
IS  - 0899-1987 (Print)
IS  - 0899-1987 (Linking)
VI  - 23
IP  - 2
DP  - 1998 Oct
TI  - A novel splice variant of HER2 with increased transformation activity.
PG  - 62-8
AB  - The HER2 proto-oncogene (also known as neu or c-erbB-2) belongs to the epidermal 
      growth factor receptor family. HER2 is frequently amplified in human carcinomas. 
      Gene amplification or overexpression of HER2 has been correlated with poor 
      prognosis in several human cancers. Point mutation in the rat HER2 homolog, neu, 
      is involved in the formation of rat neuroblastomas. However, no similar mutation 
      in HER2 has been found in human cancers. Here we report the identification of a 
      novel alternative splicing form of HER2 (deltaHER2) in human cell lines. An exon 
      16 amino acids long in the extracellular domain was deleted in deltaHER2. 
      Deletion mutations in the corresponding region were shown previously to be 
      involved in the formation of mammary carcinomas in transgenic mice. In the 
      focus-formation assay, deltaHER2 showed much stronger transformation activity 
      than did wild-type HER2. This result suggests that the deleted 16-amino acid exon 
      may play a regulatory role in HER2 transformation activity.
FAU - Kwong, K Y
AU  - Kwong KY
AD  - Department of Tumor Biology, The University of Texas M. D. Anderson Cancer 
      Center, Houston 77030, USA.
FAU - Hung, M C
AU  - Hung MC
LA  - eng
SI  - GENBANK/X03363
GR  - CA 16672/CA/NCI NIH HHS/United States
GR  - CA 58880/CA/NCI NIH HHS/United States
GR  - CA 60856/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Carcinog
JT  - Molecular carcinogenesis
JID - 8811105
RN  - 0 (DNA, Complementary)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - CHO Cells
MH  - COS Cells
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Cricetinae
MH  - DNA, Complementary
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Proto-Oncogene Mas
MH  - *RNA Splicing
MH  - Receptor, ErbB-2/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Cells, Cultured
EDAT- 1998/11/10 03:02
MHDA- 2000/06/20 09:00
CRDT- 1998/11/10 03:02
PHST- 1998/11/10 03:02 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/11/10 03:02 [entrez]
AID - 10.1002/(SICI)1098-2744(199810)23:2<62::AID-MC2>3.0.CO;2-O [pii]
AID - 10.1002/(sici)1098-2744(199810)23:2<62::aid-mc2>3.0.co;2-o [doi]
PST - ppublish
SO  - Mol Carcinog. 1998 Oct;23(2):62-8. doi: 
      10.1002/(sici)1098-2744(199810)23:2<62::aid-mc2>3.0.co;2-o.