PMID- 9846488
OWN - NLM
STAT- MEDLINE
DCOM- 19981231
LR  - 20240109
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 9
IP  - 5
DP  - 1998 Nov
TI  - IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and 
      proliferation.
PG  - 669-76
AB  - The IL-15 receptor alpha subunit (IL-15Ralpha) mediates high-affinity binding of 
      IL-15, a pleiotropic cytokine implicated in the development of innate immune 
      cells. We have generated IL-15Ralpha null (IL-15Ralpha-/-) mice to understand the 
      role of IL-15Ralpha in immune development and function. IL-15Ralpha-/- mice are 
      markedly lymphopenic despite grossly normal T and B lymphocyte development. This 
      lymphopenia is due to decreased proliferation and decreased homing of 
      IL-15Ralpha-/- lymphocytes to peripheral lymph nodes. These mice are also 
      deficient in natural killer cells, natural killer T cells, CD8+ T lymphocytes, 
      and TCRgammadelta intraepithelial lymphocytes. In addition, memory phenotype CD8+ 
      T cells are selectively reduced in number. Thus, IL-15Ralpha has pleiotropic 
      roles in immune development and function, including the positive maintenance of 
      lymphocyte homeostasis.
FAU - Lodolce, J P
AU  - Lodolce JP
AD  - Department of Medicine, The University of Chicago, Illinois 60637, USA.
FAU - Boone, D L
AU  - Boone DL
FAU - Chai, S
AU  - Chai S
FAU - Swain, R E
AU  - Swain RE
FAU - Dassopoulos, T
AU  - Dassopoulos T
FAU - Trettin, S
AU  - Trettin S
FAU - Ma, A
AU  - Ma A
LA  - eng
GR  - CA-14599/CA/NCI NIH HHS/United States
GR  - DK-42086/DK/NIDDK NIH HHS/United States
GR  - DK52751/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Il15ra protein, mouse)
RN  - 0 (Receptors, Interleukin-15)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/cytology/immunology/*physiology
MH  - CD8-Positive T-Lymphocytes/cytology/immunology/physiology
MH  - Cell Movement/physiology
MH  - Homeostasis/*physiology
MH  - Killer Cells, Natural/immunology/physiology
MH  - Lymph Nodes/cytology/immunology/*physiology
MH  - Lymphocyte Activation/*physiology
MH  - Mice
MH  - Receptors, Interleukin-15
MH  - Receptors, Interleukin-2/genetics/immunology/*physiology
MH  - T-Lymphocytes/cytology/immunology/*physiology
EDAT- 1998/12/10 00:00
MHDA- 1998/12/10 00:01
CRDT- 1998/12/10 00:00
PHST- 1998/12/10 00:00 [pubmed]
PHST- 1998/12/10 00:01 [medline]
PHST- 1998/12/10 00:00 [entrez]
AID - S1074-7613(00)80664-0 [pii]
AID - 10.1016/s1074-7613(00)80664-0 [doi]
PST - ppublish
SO  - Immunity. 1998 Nov;9(5):669-76. doi: 10.1016/s1074-7613(00)80664-0.