PMID- 9847373
OWN - NLM
STAT- MEDLINE
DCOM- 19990128
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 73
IP  - 1
DP  - 1999 Jan
TI  - Human cytomegalovirus UL69 protein induces cells to accumulate in G1 phase of the 
      cell cycle.
PG  - 676-83
AB  - Earlier studies have revealed that human cytomegalovirus rapidly inhibits the 
      growth of fibroblasts, blocking cell cycle progression at multiple points, 
      including the G1-to-S-phase transition. The present study demonstrates that the 
      UL69 protein, a virus-encoded constituent of the virion, is able to arrest cell 
      cycle progression when introduced into uninfected cells. Expression of the UL69 
      protein causes U2 OS cells and primary human fibroblasts to accumulate within the 
      G1 compartment of the cell cycle, and serum fails to induce the progression of 
      quiescent human fibroblasts into the S phase when the protein is present. 
      Therefore, the UL69 protein is at least partially responsible for the cell cycle 
      block that is instituted after infection of permissive cells with human 
      cytomegalovirus.
FAU - Lu, M
AU  - Lu M
AD  - Department of Molecular Biology, Howard Hughes Medical Institute, Princeton 
      University, Princeton, New Jersey 08544-1014, USA.
FAU - Shenk, T
AU  - Shenk T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (ICP27 protein, human herpesvirus 1)
RN  - 0 (Immediate-Early Proteins)
SB  - IM
MH  - Cytomegalovirus/*physiology/radiation effects
MH  - G1 Phase
MH  - Humans
MH  - Immediate-Early Proteins/*physiology
MH  - S Phase
MH  - Ultraviolet Rays
PMC - PMC103874
EDAT- 1998/12/16 00:00
MHDA- 1998/12/16 00:01
PMCR- 1999/01/01
CRDT- 1998/12/16 00:00
PHST- 1998/12/16 00:00 [pubmed]
PHST- 1998/12/16 00:01 [medline]
PHST- 1998/12/16 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - 1321 [pii]
AID - 10.1128/JVI.73.1.676-683.1999 [doi]
PST - ppublish
SO  - J Virol. 1999 Jan;73(1):676-83. doi: 10.1128/JVI.73.1.676-683.1999.