PMID- 9973206
OWN - NLM
STAT- MEDLINE
DCOM- 19990225
LR  - 20131121
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 3
DP  - 1999 Feb 1
TI  - Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory 
      agent, during the promotion/progression stages of colon cancer.
PG  - 597-601
AB  - Curcumin, derived from the rhizome of Curcuma longa L. and having both 
      antioxidant and anti-inflammatory properties, inhibits chemically induced 
      carcinogenesis in the skin, forestomach, and colon when it is administered during 
      initiation and/or postinitiation stages. This study was designed to investigate 
      the chemopreventive action of curcumin when it is administered (late in the 
      premalignant stage) during the promotion/progression stage of colon 
      carcinogenesis in male F344 rats. We also studied the modulating effect of this 
      agent on apoptosis in the tumors. At 5 weeks of age, groups of male F344 rats 
      were fed a control diet containing no curcumin and an experimental AIN-76A diet 
      with 0.2% synthetically derived curcumin (purity, 99.9%). At 7 and 8 weeks of 
      age, rats intended for carcinogen treatment were given s.c. injections of 
      azoxymethane (AOM) at a dose rate of 15 mg/kg body weight per week. Animals 
      destined for the promotion/progression study received the AIN-76A control diet 
      for 14 weeks after the second AOM treatment and were then switched to diets 
      containing 0.2 and 0.6% curcumin. Premalignant lesions in the colon would have 
      developed by week 14 following AOM treatment. They continued to receive their 
      respective diets until 52 weeks after carcinogen treatment and were then 
      sacrificed. The results confirmed our earlier study in that administration of 
      0.2% curcumin during both the initiation and postinitiation periods significantly 
      inhibited colon tumorigenesis. In addition, administration of 0.2% and of 0.6% of 
      the synthetic curcumin in the diet during the promotion/progression stage 
      significantly suppressed the incidence and multiplicity of noninvasive 
      adenocarcinomas and also strongly inhibited the multiplicity of invasive 
      adenocarcinomas of the colon. The inhibition of adenocarcinomas of the colon was, 
      in fact, dose dependent. Administration of curcumin to the rats during the 
      initiation and postinitiation stages and throughout the promotion/progression 
      stage increased apoptosis in the colon tumors as compared to colon tumors in the 
      groups receiving AOM and the control diet. Thus, chemopreventive activity of 
      curcumin is observed when it is administered prior to, during, and after 
      carcinogen treatment as well as when it is given only during the 
      promotion/progression phase (starting late in premalignant stage) of colon 
      carcinogenesis.
FAU - Kawamori, T
AU  - Kawamori T
AD  - Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, New 
      York 10595, USA.
FAU - Lubet, R
AU  - Lubet R
FAU - Steele, V E
AU  - Steele VE
FAU - Kelloff, G J
AU  - Kelloff GJ
FAU - Kaskey, R B
AU  - Kaskey RB
FAU - Rao, C V
AU  - Rao CV
FAU - Reddy, B S
AU  - Reddy BS
LA  - eng
GR  - CA17613/CA/NCI NIH HHS/United States
GR  - N01-CN-55150/CN/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticarcinogenic Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Anticarcinogenic Agents/*therapeutic use
MH  - Apoptosis/drug effects
MH  - Colonic Neoplasms/pathology/*prevention & control
MH  - Curcumin/*therapeutic use
MH  - Diet
MH  - Disease Progression
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Precancerous Conditions/drug therapy
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Feb 1;59(3):597-601.